The Mary Duke Biddle Trent Semans Center for Health Education is the main educational facility for the Doctor of Medicine (M.D.) program. The six-story, 104,000-square-foot health education building opened to students in 2013 and features a floor dedicated to simulation laboratories that can transform from mock clinical exam rooms to surgery suites and emergency rooms.

Medical education administrative offices are located on 8 Searle Center Drive, Durham, NC 27710, behind the Bryan Research building and next to the Medical Center Library & Archives.